23 Mar 2015: The PLOS ONE Staff (2015) Correction: Quantitative Evaluation of the Reticuloendothelial System Function with Dynamic MRI.PLOS ONE 10(3): e0122323.https://doi /10.1371/journal.pone.0122323 View correction
To evaluate the reticuloendothelial system (RES) function by real-time imaging blood clearance as well as hepatic uptake of superparamagnetic iron oxide nanoparticle (SPIO) using dynamic magnetic resonance imaging (MRI) with two-compartment pharmacokinetic modeling.
The two-compartment model provided a good description for all data and showed a low sum squared residual for all mice (0.27±0.03). A lower Kin, a lower Kout and a lower Ke were found after clodrosome treatment, whereas a lower Kin, a higher Kout and a lower Ke were observed after liposome treatment in comparison to saline treatment (P<0.005).
Citation: Liu T, Choi H, Zhou R, Chen I-W (2014) Quantitative Evaluation of the Reticuloendothelial System Function with Dynamic MRI. PLoS ONE 9(8): e103576. https://doi /10.1371/journal.pone.0103576
Data Availability: The authors confirm that all data underlying the findings are fully available without restriction. All relevant data are within the paper and its Supporting Information files.
To evaluate the r2* relaxivity of intracellular SPIO nanoparticles, Raw 264.7 cells were incubated in presence of SPIO nanoparticles at 37°C. Iron concentrations in culture medium (DMEM) were adjusted to 0.1, 0.5, 1.0, and 3.7 mg Fe/mL. The concentration of cells in the culture medium was 2×106 cells per milliliter. After 1 hr, cells were collected and suspensioned in agarose gel (1%) for r2* relaxivity measurement. The Fe concentrations of cells were measured using same procedure as free SPIO nanoparticles. Measurements were done in triplicate.
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